Purpose: The purpose of this study was to describe adherence to self-care for hand-foot syndrome\n(HFS) and the relationship between self-care and health-related quality of life (QOL). Methods: A\ncross-sectional study was conducted on 105 consecutive outpatients with HFS. To assess self-care\nfor HFS and QOL, the participants were asked to complete self-care and HFS-14 (hand-foot syndrome\nspecific QOL) questionnaires, respectively. Multiple regression models were used to identify\nthe relationship between self-care and QOL. Results: Adherence to self-care for HFS was low,\nless than 50% for most of the items. Multivariate analysis revealed that poorer self-care ( =\n0.19; P = 0.03), depressive symptoms ( = 0.43; P < 0.0001), and being employed ( = 0.20; P =\n0.04) were independent predictors of poorer QOL scores. Conclusions: We have identified a need\nfor further research to develop effective programs of self-care in HFS.
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